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Ringelblume und HIV

Author: rbauwe@aol.com (RBauwe)

Hallo!

Die Ringelblume ist u.a. eine potente Wundheilungsdroge.
bei Herbmed und medline habe ich nun folgendes gefunden:

Biomed Pharmacother. 1997;51(4):176-80. Related Articles, Links
Anti-HIV activity of extracts from Calendula officinalis flowers.
Kalvatchev Z, Walder R, Garzaro D.
Laboratorio de Virus Animales, IVIC, Caracas, Venezuela.

Extracts of dried flowers from Calendula officinalis were examined for their
ability to inhibit the human immunodeficiency virus type 1 (HIV-1) replication.
Both organic and aqueous extracts were relatively nontoxic to human lymphocytic
Molt-4 cells, but only the organic one exhibited potent anti-HIV activity in an
in vitro MTT/tetrazolium-based assay. In addition, in the presence of the
organic extract (500 micrograms/mL), the uninfected Molt-4 cells were
completely protected for up to 24 h from fusion and subsequent death, caused by
cocultivation with persistently infected U-937/HIV-1 cells. It was also found
that the organic extract from Calendula officinalis flowers caused a
significant dose- and time-dependent reduction of HIV-1 reverse transcription
(RT) activity. An 85% RT inhibition was achieved after a 30 min treatment of
partially purified enzyme in a cell-free system. These results suggested that
organic extract of flowers from Calendula officinalis possesses anti-HIV
properties of therapeutic interest.

PMID: 9207986 [PubMed - indexed for MEDLINE]

Gruß
Reinhard




Ringelblume und HIV

Author: rbauwe@aol.com (RBauwe)

Hallo!

Die Ringelblume ist u.a. eine potente Wundheilungsdroge.
bei Herbmed und medline habe ich nun folgendes gefunden:

Biomed Pharmacother. 1997;51(4):176-80. Related Articles, Links
Anti-HIV activity of extracts from Calendula officinalis flowers.
Kalvatchev Z, Walder R, Garzaro D.
Laboratorio de Virus Animales, IVIC, Caracas, Venezuela.

Extracts of dried flowers from Calendula officinalis were examined for their
ability to inhibit the human immunodeficiency virus type 1 (HIV-1) replication.
Both organic and aqueous extracts were relatively nontoxic to human lymphocytic
Molt-4 cells, but only the organic one exhibited potent anti-HIV activity in an
in vitro MTT/tetrazolium-based assay. In addition, in the presence of the
organic extract (500 micrograms/mL), the uninfected Molt-4 cells were
completely protected for up to 24 h from fusion and subsequent death, caused by
cocultivation with persistently infected U-937/HIV-1 cells. It was also found
that the organic extract from Calendula officinalis flowers caused a
significant dose- and time-dependent reduction of HIV-1 reverse transcription
(RT) activity. An 85% RT inhibition was achieved after a 30 min treatment of
partially purified enzyme in a cell-free system. These results suggested that
organic extract of flowers from Calendula officinalis possesses anti-HIV
properties of therapeutic interest.

PMID: 9207986 [PubMed - indexed for MEDLINE]

Gruß
Reinhard